Our study on individual variability in age-related cognitive inflexibility has been published in Aging Cell.

A study by Rui Yamada, Hirotaka Nagai and colleagues, “Synaptic Mitochondrial Oxidative Stress Contributes to Individual Variability in Age-Related Cognitive Inflexibility in Mice,” has been published in Aging Cell.

Our findings in mice suggest that synaptic mitochondrial oxidative stress in the medial prefrontal cortex contributes to individual differences in age-related cognitive inflexibility. We also found that the mitochondria-targeted antioxidant MitoQ improved attentional set-shifting performance in aged mice without affecting initial learning.